Can a 48-well plate be used for high-content screening (HCS)?

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Accepted Answer

Yes, a 48-well plate can be used for high-content screening (HCS). While larger format plates such as 96- and 384-well plates are typically used in HCS due to their higher throughput capabilities, 48-well plates can still be a useful tool for screening small numbers of samples or when working with limited amounts of cells or reagents. Additionally, 48-well plates may be preferred in certain experiments where higher volumes per well are required or when cell clumping or debris is a concern. Overall, while 48-well plates have some limitations in terms of scalability, they can still be a valuable option for conducting HCS experiments.

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Can a 48-well plate be used for high-content screening (HCS)?